NOGUCHI: And, therefore, might prescribe GLP-1s based on body size alone
In the first step, NADPH reduces flavin partition, then flavin is oxidized and a redox-active disulfide bridge is reduced, thereby producing a thiolate anion and a cysteine
But true receptor downregulation through lysosomal degradation requires the cell to synthesize entirely new receptors, a process that takes considerably longer
Treatment instead centers on identifying iron and B12 deficiency, replacing missing nutrients, and monitoring patients for potential complications
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