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In vitro studies have demonstrated copper-dependent effects on superoxide dismutase (SOD) activity and anti-inflammatory cytokine expression

[DOI] [PMC free article] [PubMed] [Google Scholar] 250.Yun S.P., Kam T.I., Panicker N., Kim S., Oh Y., Park J.S., Kwon S.H., Park Y.J., Karuppagounder S.S., Park H., Kim S., Oh N., Kim N.A., Lee S., Brahmachari S., Mao X., Lee J.H., Kumar M., An D., Kang S.U., Lee Y., Lee K.C., Na D.H., Kim D., Lee S.H., Roschke V.V., Liddelow S.A., Mari Z., Barres B.A., Dawson V.L., Lee S., Dawson T.M., Ko H.S

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Role of redox regulation and lipid rafts in macrophages during Ox-LDLmediated foam cell formation

Most evidence comes from in vitro studies or small human trials, not large-scale randomized controlled trials