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Conclusion When the broader treatment effects of semaglutide were explored using both the primary and key secondary outcomes of the SELECT trial, composite NNTs which include clinically and payer-relevant events and biochemical outcomes were associated with greater risk reductions and lower NNTs compared with NNT 3P-MACE based on the trials primary CV composite endpoint alone

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Similarly, IL-2 / and CD25 / mice develop fulminant autoimmune disease characterized by lymphoproliferation, colitis, and autoantibody production (58), reinforcing IL-2s non-redundant role in immune regulation

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