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A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure

A study published in "The Journal of Clinical Endocrinology & Metabolism" in 2004 titled "Prader-Willi Syndrome Is Characterized by Elevated Fasting Plasma Peptide YY Concentrations" showed that fasted plasma PYY levels are elevated in individuals with PWS when compared to control groups matched by body mass index, body composition, and sex

In addition, treatment of a DPP-4 inhibitor in diabetic mice increased the levels of anti-inflammatory cytokines, and increased the activation of regulatory T cells, indicating an involvement in the pathology of diabetes (Tian et al., 2010)