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In the SURPASS-2 trial published in the New England Journal of Medicine, participants treated with tirzepatide (5 mg, 10 mg, or 15 mg weekly) experienced reductions in fasting triglycerides from baseline over 40 weeks, with greater reductions generally seen at higher doses

No liquid, no syringe, minimal temperature sensitivity compared to reconstituted solutions

Distinct effects of semaglutide and tirzepatide on metabolic and inflammatory gene expression in brown adipose tissue of mice fed a high-fat, high-fructose diet

10.1073/pnas.1512243112 Proc

PBMs and plans are also responding to shifting rebate demand and formulary decisions tied to negotiated prices