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Efficacy and safety of liraglutide for overweight adult patients with type 1 diabetes and insufficient glycemic control (Lira-1): a randomised, double-blind, placebo-controlled trial

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Clinical trials show gastrointestinal side effects (nausea, vomiting, constipation) affect 20-40% of users across semaglutide, tirzepatide, and retatrutide, but severity and persistence vary widely