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M2 and M3 were 50% and 10% produced in respect to the native MRP1 but still correctly addressed as labeled at the plasma membrane level

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for example, the greatest fold changes for alanine were observed among the most sensitive cells to MTX, whereas 2-oxoglutarate (-ketoglutarate) greatest fold changes were found among the most resistant cells to the antifolate ( Figure 1C )

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