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Detecting oxidative modification of biomolecules with isotope dilution mass spectrometry: sensitive and quantitative assays for oxidized amino acids in proteins and tissues

35 Hyperglycemia promotes the increased expression of lncDACH1, which in turn promotes mitochondrial oxidative stress and apoptosis through increased ubiquitination-mediated degradation of NAD-dependent deacetylase sirtuin-3 (SIRT3), mitochondrial in mouse hearts, consequently aggravating DCM