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Semaglutide is indicated in combination with a reduced calorie diet and physical activity to reduce excess body weight and maintain weight reduction long term in adults with obesity (BMI 30 kg/m2) or who are overweight (BMI 27 kg/m2) in the presence of at least one weight-related comorbid condition (high blood pressure, high cholesterol, pre-diabetes, etc)

As mentioned above, tirzepatide is a dual agonist

Rare sugar D-psicose protects pancreas -islets and thus improves insulin resistance in OLETF rats

At the highest tested dose, patients averaged 21% body weight reduction over 68 weeksfar exceeding results from older GLP-1 agents alone