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However, irbesartan (an ARB) increases time spent in the center of the OFT and elevates the 5-HT levels in UCMS rats (100), suggesting the biphasic response of Ang II on 5-HT synthesis (166)

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A small molecule enhancing MET activity (the MET agonist NDX-1017 or ATH-1017) was recently tested in AD patients (NCT03298672), resulting in positive outcomes in terms of brain network activity, even if larger studies need to be performed to show more robust and statistically significant results