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[PubMed: 2821426] 123

Rodrigues DGB, Coelho D de M, Sitta , Jacques CED, Hauschild T, Manfredini V, Bakkali A, Struys EA, Jakobs C, Wajner M (2017) Experimental evidence of oxidative stress in patients with l-2-hydroxyglutaric aciduria and that l-carnitine attenuates in vitro DNA damage caused by d-2- hydroxyglutaric and l-2-hydroxyglutaric acids

Ovarian expressions of NF-B, iNOS, FOXO1, P53, and caspase-3 decreased significantly, while SIRT1, STAR, CYP17A1, HSD17B3, Nrf2, and mtDNA increased significantly

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A mutation mimicking ligandinduced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers