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Similarly, both a larger sample size and longer follow-up would have resulted in a higher number of cardiovascular events, perhaps allowing differences to be observed between persistent and non-persistent subjects

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5.8 Vitamin B12 Deficiency In metformin HCl clinical trials of 29-week duration, a decrease to subnormal levels of previously normal serum vitamin B12 levels was observed in approximately 7% of metformin-treated patients