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For detailed guidance, see our resources on GLP-1 use during breastfeeding and pregnancy while on tirzepatide

A couple of other considerations include gallbladder disease risk, rarely pancreatitis, and then there's a potential for loss of muscle mass with rapid weight reduction

For example, INT-777 and MN6, TGR5 selective agonists, stimulated GLP-1 secretion and improved insulin sensitivity in diet-induced obesity (DIO) mice [180, 181]

This is a normal physiological response, not a sign that your injection or oral medication has become ineffective

Instead of three large meals, aim for 4-5 smaller meals throughout the day