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With meals: Some experts recommend taking L-carnitine with a meal, particularly those containing carbohydrates and protein, as this can increase insulin levels and help transport L-carnitine into muscle cells

A DXA substudy of 160 participants from SURMOUNT-1 found that pooled tirzepatide doses reduced body weight, fat mass, and lean mass all significantly more than placebo, while the proportion of weight lost as fat versus lean mass stayed similar across age and sex subgroups