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This information may help provide context for how your body might respond to tirzepatide, informing whether monotherapy could be sufficient or combination strategies warrant exploration
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Concretely, GPX4 uses GSH as the substrate to reduce phospholipid hydroperoxides (PLOOHs) to hydroxyl derivatives (PLOHs), and oxidizes GSH to GSSH, therefore alleviating the damage of oxidative stress to tumor cells (Stockwell, 2022)
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