does tirzepatide cause allodynia GLP-1 Drugs: New Reports of Dysesthesia and Skin reactions (allodynia) long term

In any patient on a bisphosphonate who reports new-onset hip or thigh pain without a clear traumatic mechanism, this should be communicated to the medical team promptly

31,35-37 Prospective trials are needed to further explore this potential adverse event and worsened DR, which is the central premise of the ophthalmic FOCUS trial that is expected to release results in 2026

[19] In addition to deteriorating memory and cognitive function, the changes in body composition that are most pronounced in normal aging include a reduction in bone density and in muscle mass and strength, an increase in body fat, and adverse changes in lipoprotein profiles

Side effects, appetite changes, and body composition results vary

Pharmacological research , 151 , 104554.