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Similarly, in bipolar disorder, particularly during depressive episodes, patients exhibit altered energy metabolism marked by increased lactate levels and decreased glucose and glycine levels, which parallels results in ME/CFS that suggest TCA impairment and energy metabolism dysregulation (Yamano et al., 2016

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The influence of dopamine agonists and antagonists on indomethacin lesions in stomach and small intestine in rats

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In addition, cancer cells often have impaired methylation pathways, which can further reduce glutathione levels