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Plaintiffs point to pre-approval clinical trials and post-marketing adverse event reports that accumulated evidence of severe gastrointestinal complications years before manufacturers updated warning labels to reflect these serious risks

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p = 0.0005 at 24 h

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Summary Keywords brain-gut axis, food intake, gastrointestinal functions, HPA, hypothalamus, stress Citation Stengel A and Tach YF (2017) Activation of Brain Somatostatin Signaling Suppresses CRF Receptor-Mediated Stress Response