For instance, laboratory tests from Novo Nordisk, the manufacturer of Wegovy and Ozempic, have shown that these semaglutide formulations can safely stay unrefrigerated for up to 28 days for Wegovy and 56 days for Ozempic without losing efficacy or risking contamination
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Similarly, those who were prescribed the drug to treat overweight or obesity were over seven times more likely to receive a NAION diagnosis than people taking other weight loss drugs
Rare but Serious Side Effects of GLP-1s In rare instances, the delayed gastric emptying caused by GLP-1 medications can contribute to or exacerbate conditions like: Gastroparesis (Stomach Paralysis): This is a disorder where the stomach muscles move food through the digestive tract very slowly or stop altogether, not due to a physical blockage, but due to impaired nerve function
Before combining medications, discuss optimizing your current therapy by ensuring adequate dosing and treatment duration, exploring FDA-approved alternatives like tirzepatide or phentermine-topiramate ER, intensifying lifestyle interventions with behavioral therapy, or considering metabolic surgery if you meet clinical criteria