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"In addiction medicine, a lot of treatments target just one thing for example, a nicotine patch helps with smoking, but not alcohol but there is no medication that works across addictive substances, let alone all of them," said senior author Ziyad Al-Aly, a WashU Medicine clinical epidemiologist

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Bariatric surgery remains the gold standard for severe obesity (BMI 40 or 35 with complications)

Certain compounds, when taken orally, undergo significant metabolism in the digestive system and liver before reaching systemic circulation

The obesity drug market is currently valued at $2.82 billion and could reach $54 billion by 2030 with the advent of drugs like GLP-1 agonists that have clinically proven weight loss effects