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49 Selective serotonin reuptake inhibitors (SSRIs), a class of antidepressants that have been proven to successfully treat clinical depression, were developed in response to this hypothesis, which was derived primarily on the basis of the pharmacological mechanism of drug that were accidentally discovered to act as antidepressants

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Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimers disease