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Upon tissue disruption, danger-associated molecular patterns (DAMPs) Such as extracellular ATP, high-mobility group box 1 (HMGB1), and uric acid crystals are released from damaged cells [26, 27], while PAMPs from the wound microbiome including lipopolysaccharide (LPS) from Gram-negative bacteria, lipoteichoic acid from Gram-positive bacteria, and bacterial DNA-are detected by pattern recognition receptors (PRRs) such as NLRP3, AIM2, or NLRC4 [28]

Lee, H., Lim, S.I., Shin, S.H., Lim, Y., Koh, J.W., and Yang, S., ACS Omega , 2019, vol

Dalton SE, Pietro OD, Hennessy E

Well also do a physical exam and check your penis for plaques

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