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However, the term neutralization can also be used to describe antiviral activities of antibodies such as protection in vivo, which may or may not involve neutralization in terms of blocking viral entry

Furthermore, disease models based on the transgenic expression of ALS-associated mutations in vivo have been used extensively to investigate ALS pathogenesis and motor neuron degeneration (Taylor et al., 2016)

Each of these steps represents a potential bioavailability barrier

But it is worth being precise: these are proposed and studied mechanisms, not settled clinical facts