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Funding This work was supported by grants from the National Natural Science Foundation of China (81788101, 82171798, 81801635, 81803848, and 32141004), the CAMS Innovation Fund for Medical Sciences (CIFMS) (2021-I2M-1-040,2021-I2M-1-017,2021-I2M-1-047,2021-I2M-1-016 and 2021-I2M-1-026)

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