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UchidaK.ShiraishiM.NaitoY.ToriY.NakamuraY.OsawaT.1999Activation of stress signaling pathways by the end product of lipid peroxidation, 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production.Journal of Biological Chemistry.274223422420021-9258 70

A large percentage of these two reduced electron carriers are generated in the TCA cycle by the oxidation of the acetyl-CoA derived from pyruvate via the actions of the pyruvate dehydrogenase complex (PDHc)

Current 2024 multi-society guidance suggests most patients can continue GLP-1 agonist therapy with appropriate risk stratification rather than routine holds

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