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The reaction proceeds via the alpha-chloroamido derivative of the GSH-brostallicin adduct, is able to alkylate DNA in a sequence-specific manner and appears to be the active form of the drug, brostallicin cytotoxicity of brostallicin is higher in cells overexpressing either the GST-pi or the GST-mu gene Products: -

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Consistent findings across studies: Wrinkle reduction of 20 to 30 % in 12 weeks Increased skin elasticity of 25 to 40 % Improved hydration (increased stratum corneum hydration) Reduction of hyperpigmentation of ~30 % Thickening of the dermis (direct DXA measurements) Why it matters: GHK-Cu is the best-validated anti-aging peptide in dermatology

C9orf72 repeat expansion causes cellular dysfunction through dipeptide repeat production and C9orf72 loss-of-function

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