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Plasma DPP-4 activity ( A and C ), plasma TG and AUC over 180 minutes ( B and D , left and middle), and plasma levels of active GLP-1 before and 10 minutes after oral gavage of olive oil ( B and D , right) during a lipid tolerance (LTT) in response to water or a gut-selective (14 g/mouse) or systemic (10 mg/kg) dose of sitagliptin in 10- to 13-week-old Dpp4 Gut+/+ ( A and B , n = 1421/group) and Dpp4 Gut/ ( C and D , n = 719/group) mice fed a regular chow (RC) diet

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10.1016/j.biopha.2018.10.092 143 MarcinkiewiczJ

The most common: transient flushing or headache in the first 23 administrations as vasodilation occurs, and mild water retention (12 kg) within the first month