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However, shRNA-mediated repression of FOXO4 would be complicated to translate to the clinic

Indeed, in the NAC arm in FAS population, two neonatal prematurity-related events were reported (with a diagnosis of sepsis and respiratory distress), whereas, in the placebo arm, fourteen events were diagnosed, due to seven diseases (4 cases of respiratory distress, 3 cases of BPD, 1 case of sepsis, 1 case of NEC, 2 cases of ROP, 3 cases of intraventricular hemorrhage) (Table 2A)

doi: 10.1002/ptr.8219 190 ZhuWWangMJinLYangBBaiBMutsinzeRNet al

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