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Gut microbiota and host metabolic homeostasis Host lipid metabolism The gut microbiota plays an important role in host lipid metabolism process

"This work not only highlights the potential off-target effect of semaglutide as an effective drug to treat metabolic osteoarthritis," the team from China and the US writes in their published paper, "but also reveals a weight loss-independent repair mechanism." In addition to mouse experiments, the researchers also conducted a randomized human trial to assess the effects of semaglutide on pain, mobility, and tissue degradation in individuals with osteoarthritis and obesity

Lifestyle changes remain the cornerstone of long-term weight management

Combining semaglutide with certain drugs, supplements, or foods can lead to cumulative risks, exacerbating its adverse effects

But one researcher, John Cawley, a professor of economics and public policy at Cornell University, and his colleagues found that while obesity basically doubles a persons annual health care costs, the savings associated with public insurance plans covering GLP-1s for just obesity treatment are dependent on the patients body mass index, or BMI