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However, given that the healthy gut is immunologically primed to detect and prevent bacterial penetration, it is likely that an integral homeostatic signaling mechanism, which maintains the integrity of the gut barrier, exists to facilitate microbiota-gut-brain signaling

However, the diarrhea estimates were of low certainty due to high heterogeneity and wide confidence intervals, as indicated in Supplementary Table 7C

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Nauck MA, Quast DR (2021) Cardiovascular safety and benefits of semaglutide in patients with type 2 diabetes: findings from SUSTAIN 6 and PIONEER 6