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This is the basis for twice-daily dosing

189,190 NLGNs can participate in the formation of glutamatergic and GABAergic synapses in an activity-dependent manner

In particular, this nosology is characterized by PRKAR1A mutations

However, under defined pathophysiological stresses, including inflammatory cues, metal overload, cysteine deprivation, or drug exposure, GSH oxidation and thiol chemistry may become coupled to metal redox cycling and mitochondrial damage amplification, thereby increasing susceptibility to forms of regulated cell death such as ferroptosis and cuproptosis