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In macrophage-lineage cells, experimental folate restriction enhances proinflammatory responses, consistent with a model in which limited methyl-donor availability constrains methyltransferase activity and shifts signaling toward activation (114,115)

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In response to reports of stomach paralysis, Novo Nordisk the manufacturer behind Ozempic and Wegovy noted that these drugs have been used to treat type 2 diabetes for more than 15 years, and for the treatment of obesity for eight years

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