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In dapagliflozin and metformin HCl extended-release-treated patients with a diagnosis or strong suspicion of lactic acidosis, prompt hemodialysis is recommended to correct the acidosis and remove accumulated metformin (metformin HCl is dialyzable, with a clearance of up to 170 mL/min under good hemodynamic conditions)

They are legal in the US under specific conditions, but they do not go through the same approval process as branded drugs

Aging: A persons dietary needs, preferences, and intolerances can change as they grow older, particularly when they begin taking medications that may interact with foods they could previously enjoy