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Although the precursor lesion has invariably been present since birth or early childhood, malignant transformation occurs in an age group typically greater than 45 years, 94 with a male preponderance

Odawara M, Yoshiki M, Sano M, Hamada I, Lukashevich V, Kothny W

Although a clear definition of the cause-effect role cannot be given at present, a growing body of evidence indicates that high levels of ROS induce distinct pathological consequences that greatly amplify and propagate liver injury, leading to irreversible cell and tissue degeneration

The downward cycle can be feeling anxious or depressed, drinking to numb it and then getting worse from the alcohol, needing more alcohol, and so on

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