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5.3 Ferroptosis-targeted therapeutic strategies in coronary heart disease 5.3.1 Inhibiting ferroptosis in coronary atherosclerotic plaques The pathogenesis of coronary atherosclerotic plaques involves iron accumulation and lipid peroxidationhallmarks of ferroptosis

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It has been studied in both the TACT and TACT II Trials of the NIH

There are small human studies

Consequently, targeting PARP enzymes may offer a promising therapeutic strategy for addressing age-related diseases and disorders linked to accelerated aging