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It inhibits NNMT (nicotinamide N-methyltransferase), an enzyme regulating metabolism, fat storage, and NAD+ consumption.[4][27][6] NNMT methylates nicotinamide, a NAD+ breakdown product, diverting it from recycling and reducing available NAD+

Caution is recommended in patients with a psychotic disorder (e.g., schizophrenia due to insufficient data

Receiving B12 injections may delay a formal diagnosis of deficiency

Pyridoxine (vitamin B6) is essential for the normal functioning of the central and peripheral nervous system

The Guidelines are intended to give an understanding of a clinical problem, and outline one or more preferred approaches to the investigation and management of the problem