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Systemic Infection: In rare cases, bacteria can enter the bloodstream, leading to more severe illness

Blood pressure and pulse should be monitored regularly, particularly during dose titration of either medication

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But it can also apply to older medications like phentermine or metformin when prescribed for weight loss rather than their original FDA-approved uses

Peptide bond nitrogen atoms of Gly-473 and Gly-474 appear to form hydrogen bonds with the negatively charged oxygen atom, thereby stabilizing the transition state (Figure 5B)