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A Phase 2 trial (NEJM, 2023) reported a mean body weight reduction of approximately 24.2% over 48 weeks at the highest dose in adults with obesity without type 2 diabetes

When GLP-1 signaling is impaired as is common in insulin resistance, Type II diabetes, and chronic metabolic dysfunction the consequences are widespread: blood sugar instability, persistent hunger, difficulty losing weight, and a higher risk of cardiovascular disease and cognitive decline

YB, CA, GC, FD, and SL performed the experiments