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19 Under oxidative stress, the glutathione (GSH) level in cardiomyocytes decreases by 6070%, and the levels of Gln, glutamate and -ketoglutarate (-KG) also decrease significantly, while the enzyme activity of GLS, which converts Gln to glutamate, is enhanced

6 Interstitial cystitis and bladder pain syndrome (IC/BPS) are terms used to describe chronic bladder pain or pressure along with urinary symptoms such as urgency, frequency, and sleep disruption due to the need to urinate

194 The pathophysiology is thought to involve ischemia due to microangiopathy and metabolic disturbances