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Methylprednisolone is metabolized by the liver and excreted by the kidneys

The effect of semaglutide compared to placebo on estimated GFR was calculated using a MMRM model with two-sided P-values and with fixed effects for treatment, visit, baseline log-transformed UACR, the interaction between treatment and visit, and the interaction between baseline and estimated GFR

"Glucagon-Like Peptide-1 Receptor Agonists and Risk of Neovascular Age-Related Macular Degeneration"