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"N-acetylcysteine in depressive symptoms and functionality: a systematic review and meta-analysis." J Clin Psychiatry

Although little evidence supports the routine use of supplemental thiamin in CHF patients, trials specifically in CHF patients with marginal thiamin status have not been done, and some suggest that it may be prudent to screen patients on long-term diuretic therapy for thiamin deficiency and treat accordingly (84)

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This has made DSIP a subject of interest for researchers investigating non-addictive approaches to pain pathway modulation