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Yes, your healthcare provider will likely reduce your glipizide dose when initiating Rybelsus to minimise the risk of hypoglycaemia, as both medications lower blood glucose through different mechanisms

Compared with other antidiabetic or weight-reducing treatments, GLP-1 receptor agonists produced increased gonadotropins and sex hormone-binding globulin and improved erectile function, with serum androgen levels comparable to or exceeding those of other agents

For example, Exanatide alone, or in combination with insulin therapy or immunosuppressants, such as daclizumab, but did not improve C-peptide secretion (Rother et al, 2009)

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But here we are more likely to use the C rating rather than the 20 hour rate