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Unlike growth hormone peptides (which work through the pituitary) or GLP-1 peptides (which work through gut and brain receptors), BPC-157 works primarily through a different mechanism: it upregulates growth hormone receptors in tendon cells, stimulates angiogenesis (the formation of new blood vessels), and modulates nitric oxide signaling all of which contribute to accelerated tissue repair and reduced inflammation
While that gap is meaningful, it was not dramatic enough for AOD-9604 to win approval as a standalone obesity drug, and formal development was paused in 2007
If side effects are intolerable on one, switching to the other is a reasonable option
Individuals adhering to a vegetarian or vegan diet, those aged 50 and above, or people experiencing malabsorption issues are at a higher risk of developing a deficiency
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