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Importantly, the enzymatic activity of TETs is regulated by 2-oxoglutarate (2OG) as a cofactor and suppressed by metabolites such as 2-hydroxyglutarate (2HG) as a competitor of 2OG

Epitalon Traditional antioxidants such as vitamin C, vitamin E, and coenzyme Q10 are widely used to fight oxidative stress

Enhancement of virus infectivity Oxidative stress exacerbates the pathogenesis of coxsackievirus B3 (CVB3) infection in mice, and the change in virulence is attributed to changes in the viral genome and in the immune functions of the oxidatively stressed mice (67)

Reprod Biol Endocrinol RBE 10:1-32