Bone 80:115125 Shao M, Wang Q, Lv Q, Zhang Y, Gao G, Lu S (2024) Advances in the research on myokine-driven regulation of bone metabolism
The main analysis included all people who started treatment, regardless of any gaps in their therapy, while a sensitivity analysis evaluated outcomes only in people who did not have any gaps in their treatment lasting more than 30 consecutive days.
Metformin may still be preferred when the main concern is cost, long-term familiarity, or avoiding injectable therapy
That said, they are different drugs
Though the clinical characteristics of the severe deficiency are similar to those of the granulomatosa chronic disease (EGC), its appearance happens, unlike the latter, during more advanced stages of life 17,18