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Rather than relying solely on reduced food intake, mazdutide supports weight loss through both decreased energy intake and increased energy expenditure

Frost et al

In the rabbit study, the NOAEL for fetal toxicity was 0.5 mg/kg/day (approximately equivalent to the MRHD based on BSA) due to an increase in fetal death at 2 mg/kg

Additional diagnostic tests like an upper endoscopy or bowel biopsy may also be required

Many individuals achieve satisfactory outcomes through lifestyle intervention programs [103], bariatric surgery [104,105,106], or pharmacological interventions alone [28]