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Novo Nordisk lost patent protection for the drug in January, stemming from an error in paying a small patent maintenance fee in the nation, as originally reported by Endpoints News in 2025

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The FDA classifies phentermine as a Schedule IV controlled substance due to its stimulant properties and potential for dependence, though actual addiction rates remain low when the medication is used as prescribed

While the G6PD-d monocytes displayed the phenotypic hallmarks of M2 polarization (CD11b, CD209 expression), these cells were functionally deficient in M2 atheroprotective TGF and had increased expression of proinflammatory M1 cytokines TNF and MCP-1

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