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Neuroinflammation in Alzheimers disease: Current evidence and future directions

2 Nevertheless, it is emerging that static structures determined via x-ray crystallography or cryo-electron microscopy (cryo-EM) cannot always be extrapolated to understand receptor and transducer activation, which are inherently dynamic processes

These integrative and multidimensional interactions shape the system's behavior and must be considered comprehensively over time, space, and the context of appearance (177, 178)