More specifically, GLP-1 RAs have been linked to increased bone formation markers, such as P1NP, osteocalcin, and bone-specific alkaline phosphatase, while simultaneously reducing bone resorption markers, like -CTX (10, 11, 12)
Semaglutide and tirzepatide were originally developed to treat type 2 diabetes, but clinical evidence now supports their use in younger adults with obesity or weight-related health concerns
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However, long-term maintenance of urinary oxalate concentrations is required for stone formation [2]