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By reducing hunger and curbing overeating, these drugs can assist with weight loss, particularly in individuals who struggle with excessive food consumption

This process, known as thermogenesis, generates heat and burns calories, aiding in fat oxidation and weight loss

21 Mechanistically, the presence of GLP-1 receptors in the retina raises the possibility of a direct toxic effect of the GLP-1/GIP agonists leading to the observed retinopathy progression

Meanwhile, it also wants Lilly to conduct prospective, registry-based studies looking at safety in children and adolescents, pregnancy, and medullary thyroid cancer, as simply monitoring spontaneous postmarketing adverse events is not considered adequate for these purposes